Bone remodelling at the interface with implant – an effect of implant surface micro-structure

Good integration of metallic implant as for example endoprosthesis with a bone determines its stability and durability. There are many biological, structural and mechanical factors affecting interactions between bone tissue and a surface of prosthesis. Among the mechanical parameters local stress and strain distributions play a crucial role. The loading conditions, shape and mechanical characteristics of endoprosthesis determine an overall stress distribution in a bone and associated effect of stress shielding. However concerning the local state at the interface which is to big extent responsible for cells activities, intracellular matrix synthesis, tissue differentiation and remodelling apart from the biocompatibility and biochemical factors a micro-structure of an implant surface and its local mechanical parameters play a key role in expected good integration of a prosthesis. In the present work the results of a preliminary study of mentioned here effects are discussed.